Value of chemiluminescence assay for detecting human immunodeficiency virus antibodies :a Meta-analysis / 重庆医学

ABSTRACT

Objective To systematically evaluate the value of chemiluminescence assay for detecting human immunodeficien-cy virus(HIV) antibodies as a HIV preliminary screening method .Methods The Chinese and English studies on chemilumines-cence assay for detecting HIV antibodies published by the databases of WanFang ,VIP ,CNKI ,CBM ,Pubmed and Web of Science were collected by computer retrieval and manual retrieval .The retrieval time limit was from the database establish to November 2016 .Two reviewers independently screened the literature ,extracted the data and assessed the methodological quality of included studies .Then the meta-analysis was performed by using Meta-disc1 .4 and Stata12 .0 software .Results A total of 8 studies invol-ving 26168 patients were included .The meta-analysis results showed that the pooled sensitivity of chemiluminescence assay for de-tecting HIV antibodies was 100% (95% CI1 .00-1 .00) ,the pooled specificity was 100% (95% CI0 .99-1 .00) ,the pooled posi-tive likelihood ratio was 237 .79(95% CI80 .50-702 .42) ,the pooled negative likelihood ratio was 0 .00(95% CI0 .00-0 .02) ,the diagnostic odds ratio(OR) was 48911 .05(95% CI8257 .50-289711 .20) ,and the area under the curve(AUC) was 0 .9994(SE=0 .0002) .Conclusion Chemiluminescence assay can serve as a HIV preliminary screening method for promotion and application in clinic .