Advances in the study of long non-coding RNA in the therapy resistance of breast cancer / 医学研究生学报

ABSTRACT

The occurrence of breast cancer therapy resistance is one of the most important reasons for the failure of breast cancer treatment.Once there was therapy resistance,breast cancer patients will suffer from advance of the cancer,replace of the tumor and distance metastasis,which will cause decrease of the quality of life and increase of the mortality rate.Long non-coding RNA (lncRNA) plays a very important role in the tumorigenesis and development.There are few reports about lncRNA in the resistance of breast cancer at home and abroad,especially in the field of molecular targeted therapy.However,understanding the role of lncRNA in the therapy resistance of breast cancer can effectively improve the effectiveness of several treat approaches of breast cancer.This article reviews the function of lncRNA in breast cancer chemotherapy,endocrine therapy and molecular targeted therapy and further clarify its molecular mechanism.