Study on the correlation between prognosis and ECG changes in patients with acute spontaneous intracerebral hemorrhage / 天津医药

ABSTRACT

Objective To study the relationship between changes of electrocardiogram (ECG) and the prognosis of patients with acute spontaneous intracerebral hemorrhage. Methods The relationship between ECG changes and location data of intracerebral hemorrhage in 183 patients was analyzed. The prognosis of spontaneous intracerebral hemorrhage in acute stage and the abnormal ECG were analyzed by Logistic regression analysis. Results In 183 patients, there were 44 cases of brainstem hemorrhage, 21 cases of thalamic hemorrhage, 42 cases of basal ganglia hemorrhage and 76 cases of cerebellar hemorrhage. In these patients, there were abnormal ECG findings in 35 cases (79.5%), 16 cases (76.2%), 21 cases (50.0%) and 31 cases (40.8%). There were significant differences in the proportions of patients with ECG abnormalities in different bleeding sites (χ2=21.638,P<0.05). Abnormal ECG was more common when intracerebral hemorrhage was located at the midline structures. According to the hematoma volumes, there were 20 cases with hematoma volumes ≤ 10 mL (35.0%), 25 cases with hematoma volumes between 10 mL-30 mL (72.0%) and 18 cases with hematoma volumes≥30 mL (88.9%). There were 7 cases with abnormal ECG, 18 cases with abnormal ECG and 16 cases with abnormal ECG in these three groups of patients. There were significant differences in the proportions of patients with ECG abnormalities between three groups (χ2=12.979,P<0.05). There were more patients with abnormal ECG in hematoma volumes between 10 mL-30 mL group and hematoma volumes ≥30 mL group than those of patients with hematoma volumes ≤10 mL group (χ2=6.161 and 11.515, P<0.05). There was no significant difference in patients with ECG abnormalities between hematoma volumes of 10 mL-30 mL group and hematoma volumes≥30 mL group (χ2=1.804,P>0.05). There were 51 cases with abnormal ECG in 69 cases of death group (73.9%). There were 52 cases with abnormal ECG in 114 cases of survival group (45.6%). There was significant difference between the two groups (χ2=13.990,P<0.05). Logistic regression analysis revealed that the ST-T change, U-wave abnormality and long QT interval were risk factors for death in the acute phase of spontaneous intracerebral hemorrhage. Conclusion While actively treating primary brain diseases, we should closely monitor changes of ECG and deal with them in time so as to prevent the death of patients with acute phase of spontaneous intracerebral hemorrhage.