Influence of Panax quinquefolium saponins on oxidative damage and function of vascular endothelium in diabetic rats / 中国药理学通报

ABSTRACT

Aim To investigate the protective effect of Panax quinquefolium saponins (PQS ) on oxidative damage and function of vascular endothelium. Meth-ods After 3 days of adaptive feeding of Wistar male rats,56 rats were randomly selected as the control group,while others were induced by streptozotocin (STZ,30 mg·kg - 1 ). The diabetic rats were random-ly divided into three groupsthe model group,PQS group(100 mg · kg - 1 )and Vitamin E group (100μmol·kg - 1 ). The normal group was injected with e-qual amount of citrate buffer. PQS and Vitamin E groups of diabetic rats were administered orally once a day. After 4,8,16 weeks of administration,the con-centration of blood glucose and LPO,SOD of serum, heart and kidney were measured,and the tension of the aortic vascular ring was determined. Results Compared with model group,with prolongation of med-ication,the concentration of glucose and the LPO of serum,heart and kidney in the PQS group significantly decreased(P < 0. 05,P < 0. 01),then the results of the aortic vascular ring tension showed that acetylcho-line induced vasodilatation and maximum diastolic per-cent were obviously elevated in PQS group(P < 0. 05, P < 0. 01). Conclusion PQS could elevate the an-tioxidant function in diabetic rats,thus improving the endothelium-dependent vasodilation function and inter-fering with the occurrence and development of diabetic vascular complications