Nodular fasciitis of the breast: a clinicopathologic study of 4 cases with review of literature / 临床与实验病理学杂志

ABSTRACT

Purpose To summarize the clinicopathologic features,diagnosis and differential diagnosis of nodular fasciitis (NF) of the breast.Methods Clinicopathologic findings of four mammary NF cases were retrospectively reviewed.Immunohistochemical of EnVision staining was performed in all cases.Results The median age of all patients was 50.5 years.All patients were female,without history of trauma.The average size was 1.2 cm.Among the four cases reviewed,three lesions occurred in the mammary parenchyma and one next to the skin.Histologically,the lesion was composed of plump spindle cells arranged in short fascicles with erythrocytes extravasation and patchy lymphoid infiltration,and the border of three cases was infiltrative.Immunohistochemically,the spindle cells were positive for vimentin,CD10 and SMA,but negative for CK (AE1/AE3),CK5/6,CK14,CAM5.2,ER and PR.All patients underwent surgical resection,with no evidence of recurrence.Conclusion NF of the breast is rare.It should be differentiated from some benign and malignant tumours,such as fibromatosis,phyllodes tumor and low-grade fibromatosis-like metaplastic carcinoma.The immunostaining of vimentin and SMA may helpful for the diagnosis and differential diagnosis of NF of breast.