Research progress of relationship between aromatase and glucose metabolism / 医学研究生学报

ABSTRACT

Aromatase (aromatase, CYP19) is one of cytochrome P450 enzyme, located in the cells endoplasmic reticulum .It can catalyze C19 steroids, including androstenedione and testosterone , to form estrogen (C18 steroids) by removing of the C19 carbon and aromatizing the A ring of the steroid which is controlled by P 450arom.Generally, aromatase is known for its role in reproduction , reproductive system diseases , and estrogen responsive diseases .Recently, it is found that the aromatase may be related to the occur-rence and progression of glucose metabolism disorders .This review will introduce the effects of aromatase deficiency and excess on glu-cose metabolism and its possible mechanisms .