CT-guided percutaneous biopsy for the diagnosis of mediastinalmass lesion / 医学研究生学报

ABSTRACT

Objective Few reports are seen on the application of CT-guided percutaneous biopsy ( CT-PB) in the diagnosis of mediastinal mass lesion ( MML) .This study aimed to investigate the clinical application value and safety of CT-PB in detection of MML. Methods This retrospective study included 81 patients hospitalized in our Department of Respiratory and Critical Care Medi-cine, who underwent CT-PB for MML.We performed cytological and histological examinations of the biopsy specimens and immunohisto-chemical staining on the morphologically malignant samples .With the final diagnosis as the gold standard ,we analyzedthe accuracy , speci-ficity, sensitivity, positive and negative predictive values , and com-plications of CT-PB in the diagnosis of MML . Results CT-PBwas successfully performed in all the 81 cases,definite diagnosis achieved in 77 (95.1%),malignancy detected in 68 (84%), benign lesions in 10 (12.3%),and fibrous hyperplasia /massive necrosis in 2 (2.5%).The sensitivity, specificity, and positive and negative predictive values were 94.4%, 100%, 100%and 69.2%, respectively. All the patients were well tolerated without serious complications . Conclusion For patients with mediastinalmass lesion , CT-guided percutaneous biopsy is an efficient and safe diagnostic tool with high sensitivity , specificity , and diagnostic accuracy , which may con-tribute to the subsequent treatment .