Excessive iodine and autoimmune thyroid disease / 中华地方病学杂志

ABSTRACT

Autoimmune thyroid disease (AITD) is an archetypal organ-specific autoimmune disorder that is characterized by the production of thyroid autoantibodies and lymphocytic infiltration into the thyroid.Excessive iodine can increase the incidence of AITD.During trapping,oxidation and organification of excessive iodine in thyroid cells,excessive reactive oxygen species (ROS) were generated,which induces apoptosis of thyroid cells,accelerates thyroglobulin autoantigen presentation,promotes lymphocytes infiltration and cytokine expression.Excessive iodine is an environmental risk factor which promotes the people with stealth autoimmune thyroid disease to get sick.In this article,we discussed the relationship between excessive iodine and AITD and its mechanism.