Preparation of colon-targeted pellets of Prunellae Spica effective components and the in vitro drug-release behaviors / 中成药
Chinese Traditional Patent Medicine
;
(12): 2273-2278, 2017.
Article
Dans Chinois
| WPRIM
| ID: wpr-668858
ABSTRACT
AIM To prepare colon-targeted pellets of Prunellae Spica effective components and to evaluate the in vitro drug-release behaviors.METHODS Fluidized bed coating method was adopted in the preparation of pellets.With in vitro accumulative release rate as an evaluation index,hydroxypropyl methyl cellulose (HMPC),polyacrylic resin (Eudragit S100) and triethyl citrate (TEC) amounts as influencing factors,orthogonal test was applied to optimizing the formulation.The in vitro drug-release behaviors were evaluated with rosmarinic acid content as an index.RESULTS The optimal formulation was determined to be 5% for HPMC amount,70% for Eudragit S100 amount,and 20% for TEC amount.The obtained pellets attained an accumulative release rate of more than 90% in pH 7.6 PBS (transportation for 2 h),while no drug dissolution was found in pH 1.0 HCl (transportation for 2 h) or pH 6.8 PBS (transportation for 3 h).CONCLUSION Colon-targeted pellets of Prunellae Spica effective components can achieve in vitro colon-targeted effect.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Traditional Patent Medicine
Année:
2017
Type:
Article
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