Clinical characteristics and prognostic analysis of 307 patient with high-risk gastrointestinal stromal tumors / 中华普通外科杂志

ABSTRACT

Objective To investigate the clinical characteristics,diagnosis and treatment as well as prognostic factors of high-risk gastrointestinal stromal tumors (GIST).Methods Clinical data of 307 patients with high risk GIST treated in the Union Hospital from Jan 2005 to Dec 2016 were retrospectively analyzed.Results There were 172 males and 135 females with median age of 51 (20-84) years.Tumors located in the stomach in 88 (28.7％) cases,in the small intestine in 141 (45.9％),in the colon and rectum in 27 (8.8％) and outside the gastrointestinal tract (mesentery,retroperitoneum,abdominal cavity,and pelvic) in 51 (16.6％).All underwent surgical resection,including R0 resection of 299 cases (97.4％),R1 resection of 6 cases (2.0％) and R2 resection of 2 case (0.7％).68 cases (22.1％) received postoperative imatinib 400 mg/d for 3 to 84 months.The 1-,3-,5-year overall survival rates of high-risk GIST were 95％,86％,76％,the 1-,3-,5-year recurrence-free survival rates were 92％,83％,71％.By multivariate analysis the 5-year RFS were related only to mitotic count while,there was no significant difference in the RFS in patients gender,tumor site,tumor size.Conclusions Complete surgical excision is the effective treatment for high-risk GIST.Mitotic count is the most important prognostic factor.