Preparation and Quality Evaluation of Shenhuang Vaginal Thermosensitive in situ Gels / 中国药师
China Pharmacist
;
(12): 655-659, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-669964
ABSTRACT
Objective:
To prepare and evaluate Shenhuang vaginal thermosensitive in situ gels.Methods:
Shenhuang vaginal ther-mosensitive in situ gels( SHV-TISG)were prepared with poloxamer 407 and poloxamer 188 as the materials. The viscosity change at different temperatures and the gelation temperature of SHV-TISG and SHV-TISG diluted by stimulant vaginal fluid were measured,the in vitro drug release of the preparation was evaluated by a membraneless diffusion method,and the safety of SHV-TISG was detected by vaginal irritation test.Results:
The preparation showed the vaginal injectability and gelationability in vivo without vaginal irritation. Gel erosion was the principal mechanism of the drug release from the gels.Conclusion:
The preparation of SHV-TISG is feasible in tech-nique,and the properties meet the requirements of vaginal topical use.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
China Pharmacist
Année:
2015
Type:
Article
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