Efficacy and Influence of Rat NGF on Serum Neuropeptide Y and Neuron-specificenolase Levels in New-born with Neonatal Hypoxic and Ischemic Encephalopathy / 中国药师

ABSTRACT

To discuss the therapeutic effect and influence of rat NGF on serum neuropeptide Y ( NPY) and neuron-specificenolase (NSE) levels in newborn with neonatal hypoxic and ischemic encephalopathy (HIE). Methods: Totally 70 cases of neonatal HIE patients were selected and divided into the observation group and the control group at random. The children in the two groups were given the routine medical treatment such as oxygen uptake, the control of intracranial pressure, blood pressure and blood sugar, anticonvulsant, balance of water and electrolyte and etc. The children in the observation group were additionally given 20μg rat NGF through intramuscular injection once a day. The children in the control group were additionally given 100 mg citicoline through in-travenous drip once a day. The treatment course was 10-14 days. The changes of serum NPY and NSE levels, clinical curative effect and adverse drug reactions ( ADR) in the two groups were compared, and the occurrence of nervous system sequel after the medical treatment was compared and followed up. Results: After the 2-week medical treatment, the serum NPY and NSE levels in the two groups were declined (P<0. 05 or P<0. 01), and the declining in the observation group was more notable than that in the control group (P<0. 05). The total clinical efficiency in the observation group was 94. 28%, which was much higher than that (68. 57%) in the control group (P<0. 01). No obvious adverse drug reaction appeared in the two groups during the treatment. After the one-year follow up, the occurrence of sequel was 5. 71% in the observation group, which was much lower than that (22. 86%) in the control group(P<0. 05). Conclusion:Rat NGF has reliable curative effect on neonatal HIE with high security, which can improve the repair of impaired neuronal cells, reduce the occurrence of sequel of neuronal cells and enhance the prognosis, and the mechanism may relat-ed with the reduction of serum NPY and NSE levels.