Patient-controlled Interavenous Analgesia with Butorphanol Combined with Remifentanil in Patients with Uterine Fibroids Embolization / 中国药师

ABSTRACT

Objective:To investigate the patient-controlled intravenous analgesia effect of butorphanol combined with remifentanil in uterine artery embolization for uterine myoma. Methods:Totally 68 cases of uterine fibroids patients were divided into the observa-tion group (n=35) and the control group (n=33) according to the admission order, and with time selecting operation. The control group was given fentanyl for patient-controlled intravenous analgesia, while the observation group was treated with butorphanol com-bined with remifeatanil. VAS (visual analog scale), sedation, postoperative pain and adverse reactions in the two groups were ob-served and compared. Results:VAS and sedation score of the observation group were significantly lower than those of the control groups in 1, 4, 12 and 24 h after the operation (P<0. 05). Grade 0 pain rate was 74. 3% in the observation group after the operation, which was significantly higher than that in the control group (48. 5%, P<0. 05). The incidence of adverse drug reactions in the observation group was significantly lower than that in the control group (P<0. 05). Conclusion:The combination of butorphanol and remifentanil in uterine fibroid embolization can effectively reduce postoperative pain and significantly decrease the incidence of adverse reactions with promising safety and reliability, which is worthy of promotion in clinical use.