Effect of Ouabain on Intraocular Pressure in Rabbits
Journal of the Korean Ophthalmological Society
;
: 13-15, 1970.
Article
Dans Coréen
| WPRIM
| ID: wpr-67188
ABSTRACT
Effect of Ouabain administration on aqueous humor dynamics were studied in albino rabbits. Intravenous injection of 0.1 mg/kg of ouabain in 10 rabbits produced significant reduction of intraocular pressure. The highest lowering of intraocular pressure occurred 70 minutes after the injection, its magnitude being 35.54% of the original pressure. The intraocular pressure returned to its original pressure 117.0 minutes after the injection. Perilimbal suction cup studies revealed 26.92 % reduction in aqueous flow. Intravitreal injection of O.1 micro gram of ouabain dissolved in 0.02 ml performed in 5 rabbits' eyes produced marked lowering of intraocular pressure. The maximum tension lowering effect (60.15%) was observed 4.6 days after the administration, and the tension recovered 15.8 days after the injection. Perilimbal suction cup studies showed 29.48 % reduction in aqueous flow. It is concluded that Na-K ATPase play an important role in the aqueous formation and that ouabain lowers the intraocular pressure by supressing this enzyme. Intravitreal administration has more powerful tension-lowering effect than intravenous injection.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ouabaïne
/
Humeur aqueuse
/
Aspiration (technique)
/
Adenosine triphosphatases
/
Injections intravitréennes
/
Injections veineuses
/
Pression intraoculaire
Limites du sujet:
Animaux
langue:
Coréen
Texte intégral:
Journal of the Korean Ophthalmological Society
Année:
1970
Type:
Article
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