Screening of in vitro cytotoxic activity of some medicinal plants used traditionally to treat cancer in Chhattisgarh state, India

ABSTRACT

Objective:To explore the cytotoxic activity of the alcoholic extracts of some medicinal plants used traditionally to treat cancer in Chhattisgarh state, India. Methods:In-vitro cytotoxicity of alcoholic extracts of five plants i.e. Artocarpus heterophyllus, Alangium salvifolium, Buchanania lanzan, Sesbania grandiflora and Wrightia tinctoria was studied against human breast cancer (MCF-7) and human leukemia (HL-60) tumor cell lines, using the thiazolyl blue test (MTT) assay. Results: Alcoholic extract of Sesbania grandiflora exhibited a prominent inhibitory effect against MCF-7 (IC50 7.00±0.08μg/mL) and HL-60 (IC50 18.50±0.60μg/mL) under in vitro condition. Conclusions:From the result it can be found that the Sesbania grandiflora extract has potent in vitro cytotoxic activity.