Detection of blocking antibodies in sera of RSA / 中国免疫学杂志

ABSTRACT

Recurent spontaneous abortion (RSA) was classified into the primary (1?) and the sec-ondary (2?) according to patients histoty.Occurence of blocking antibodies between them wasinvestigated with mixed lymphocyte reaction—blocking assay and complement dependent cyto-toxicity assay.It was found that the primary abortion had been mainly caused by lack of block-ing antibodies,the secondary abortion without lack of blocking antibodies.Thus,the primaryabortion is different from the secondary abortion in aspects of immune aetiology and immunemechanisms although their clinical manifestations are similar.