Experiment Study of Radioactive Distribution of Intrahepatically Injected ~(90)Y Glass Microsphere / 中华超声影像学杂志

ABSTRACT

Different doses of ~(90)Y glass microspheres weres injected into the livers of rabbits under ultrasound guidance to observe the distribution of isotope in the body and the histologic alteration in the liver. The result showed that the isotope microspheres were only limited at the injected areas. The areas o.f bremsstrahlung ranged 4.1～12.55cm~2(mean 8.45cm~2). Whole body scanning revealed that the isotope was not observed outside the liver and no injury of non-target organ was present. When the dose was 35 mci, complete necrosis appeared in the hepatic cells within the bremsstrahlung areas. The study indicales that intrahepatic injection of ~(90)Y glass microspheres is accurmuate in locallization, produces high local iradiation energy and may become a non-surgical way for treating carcinoma of liver.