Human ?-cells destruction correlates with Fas expression on ?-cells induced by IFN-? and TNF-? / 中国免疫学杂志

ABSTRACT

Objective:To study the effect of increased expression of Fas on the killing of ? cells Methods:The level of Fas expression and apoptosis of human ? cells strain (NIT) were detected by FACS Results:There is no Fas expression on NIT But Fas expression can detected by culturing NIT with IFN ? and/or TNF ? The apoptosis of NIT induced by sFasL and anti Fas correlates with the level of Fas expression Conclusion:Fas expression induced by cytokine may represent a factor for the initiation of ? cells destruction