Biweekly regimen of high-dose leucovorin, fluorouracil and oxaliplatin for advanced and refractory colorectal cancer / 中国癌症杂志

ABSTRACT

Purpose:To evaluate the efficacy and toxicity of the biweekly regimen of high dose leucovorin (CF), continuous central venous infusion(ccvi) of fluorouracil (5 FU) and oxaliplatin (OXA)for advanced and refractory colorectal cancer.Methods:28 patients (12 in rectum,16 in colon) received biweekly CF/5 FU/OXA (CF 200 mg/m 2,ccvi 2 hour,days 1～2;5 FU400mg/m 2,iv.,day 1; 5 FU 1.6 g/m 2,ccvi.22 hours, days 1～2; OXA 135 mg/m 2,ccvi.4 hour,day 1,every two weeks).Four treatment courses were carried out with an interval of one month.Results:The overall response rate was 39.28%.The response rates of rectal,colonic cancers were 33.33%% and 43.13%, respectively.Median duration of 11 partial responses were 5.0 months.Median survival of all patients was 7.0 months. Median survival of responsive patients,and non responsive was 11.0 and 7.0 months,respectively( P