Oxaliplation and flurouracil in combination with concurrent radiotherapy for advanced rectal cancer / 中国癌症杂志
China Oncology
;
(12)2001.
Article
Dans Chinois
| WPRIM
| ID: wpr-675123
ABSTRACT
Purpose:
To evaluate the effect of oxaliplation (L-OHP)+flurouracil/calcium folinate(5-FU/CF) in combination with concurrent radiotherapy for advanced rectal cancer and to find a more effective way of giving them.Meth- odsChemotherapyL-OHP 130 mg/m~2,iv infusion for 2 hours D_1 combined with calcium folinate 200 mg/m~2 for 2 h ours followed by 5-fluorouracil 300 mg/m~2 for 4h D_1~D_5,repeated every 3 weeks.RadiotherapyThe whole pelvic irradiation DT 50~60Gy/25~30/F(5~6 weeks).Results:
30 advanced rectal cancer patients entered the study.One patient reached complete response(CR),15 partial response,13 stable disease,and 1 with progression after treatment,The overall re- sponse rate(CR+PR) was 53.3%,the 1-year survival rate was 70% (21/30).The main adverse acute effects were gas- trointestinitis,anemia,neuro-sensory toxicity and irradiation rectitis,bone marrow suppression was mild.Conclusions:
This approach of therapy could improve the therapeutic effect on advanced rectal cancer.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
China Oncology
Année:
2001
Type:
Article
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