Preliminary study on antitumor effect of active specific immunotherapy with autologous tumor vaccine in post-operative patients with advanced tumors / 中国免疫学杂志
Chinese Journal of Immunology
;
(12)2001.
Article
Dans Chinois
| WPRIM
| ID: wpr-675149
ABSTRACT
Objective:
The explore the mechanism of active immunotherapy with autologous tumor vaccine and clinical significance.Methods:
30 patients with advanced tumors were enrolled in this study.4 weeks after operation,the patients received vaccinations of autologous tumor vaccine every 7~10 days for 4 times as adjuvant active immunotherapy,3 days before and 7 days after administrationsperipheral blood monuclear cells(PBMC) were isolated to assay the alteration of proportions of CD + 8 IFN ? + and CD + 8 IL 10 +,CD + 4 IFN ? + and CD + 4 IL 10 + cells.Meanwhile,serum IFN ? and IL 10 were measured within 48 hours after the skin tests with PPD and autologous tumor antigen,diameters of erythemas or indurations were observed.The clinical follow up was performed.Results:
After active immunotherapy with autologous tumor vaccine.①The serum IFN ? was increased from (5.98?2 40)pg/ml to (11.20?4.76) pg/ml(P
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Immunology
Année:
2001
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS