Improvement of high glucose toxicity-induced insulin desensitivity by nitric oxide in diabetic rats / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
; (12)1985.
Article
de Zh
| WPRIM
| ID: wpr-675792
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To observe whether nitric oxide (NO) improves high glucose toxicity induced insulin resistance in streptozotocin (STZ) induced diabetic rats. Methods The changes of metabolic clearance rate for glucose (MCR), as the index of insulin effect, were observed in 24 STZ induced diabetic rats and 24 normal rats in awake condition treated by sodium nitroprusside (SNP), N G monomethyl L arginine (LNMMA), adenosine or saline duringeuglycemichyperinsulinemiaclampprocedure.Results MCR in saline treated diabetic rats 〔(7.2?0.8)ml?kg -1 ?min -1 〕 wassignificantlylowerthanthat in normol control rats 〔(18.0?1.8)ml?kg -1 ?min -1 , P
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Journal of Endocrinology and Metabolism
Année:
1985
Type:
Article