Effects of saturation of free fatty acids on nitric oxide and endothelin production in cultured human vascular endothelial cells / 中华内分泌代谢杂志

ABSTRACT

Corresponding author SONG Guang yao Human umbilical venous endothelial cells (HUVEC) were incubated with free fatty acids (FFAs) of various degrees of saturation. C181 and C182 inhibited the synthesis of nitric oxide (NO) and endothelin (ET) in HUVEC, and ET synthesis was inhibited much more than NO synthesis, and C180 increased ET synthesis in HUVEC, suggesting that the effects of FFAs on HUVEC were related to their degree of saturation.