TP53 Polymorphisms allow for genetic sub-grouping of the canine transmissible venereal tumor
Journal of Veterinary Science
;
: 353-355, 2009.
Article
Dans Anglais
| WPRIM
| ID: wpr-67597
ABSTRACT
The canine transmissible venereal tumor (CTVT) is found mainly in dogs' sexual organs. Currently, it is widely accepted that all samples of CTVT show similar histopathological characteristics and share common genetic alterations. Despite the common genetic origin of CTVT, mutations in the P53 gene have been reported. In this study, we proposed that tumor samples can be genetically grouped using this gene. The presence of different subgroups of CTVT was determined in Mexican dogs using the TP53 gene sequence in CTVT samples. Four new polymorphisms were found and therefore, the CTVT samples were classified in five subgroups.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polymorphisme génétique
/
Tumeurs vénériennes transmissibles de l'animal
/
Données de séquences moléculaires
/
Séquence nucléotidique
/
Régulation de l'expression des gènes tumoraux
/
Protéine p53 suppresseur de tumeur
/
Maladies des chiens
/
Mutation
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Journal of Veterinary Science
Année:
2009
Type:
Article
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