ANTIPYRETIC AND ANESTHETIC ACTIVITY OF FERULOFEN / 中国药理学通报

ABSTRACT

Ferulof en ( FL, 45mg and 200mg/kg im ) showed marked antipyretic effect on rabbit fever induced by typho-paratyhoid vaccine and on rat fever induced by yeast powder suspension respectively. Their potency and action phase were similar to those of aspirin ( 35mg and 100mg/kg) . Furthermore, it blocked the action potential of sciatic nerve in toad to some extent and had a certain local anesthetic effect on guinea pigs in intradermic wheal test, but much weaker than procaine and lidocaine at the same concentration. It had no obvious influence on corneal reflex in rabbits.It can be concluded from these findings that together with the results of previous paper the findings of this paper further indicated FL may be proved to be a new antiinflammatory, antipyretic and analgesic drug.