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Effect of N-methyl berbamine on ATP sensitive K + currents in single ventricular myocytes of guinea pig / 中国药理学通报
Chinese Pharmacological Bulletin ; (12)1986.
Article Dans Chinois | WPRIM | ID: wpr-677093
ABSTRACT
AIM To investigate the effect of N methyl berbamine(NMB)on ATP sensitive potassium currents( I KATP )in single ventricular myocytes of guinea pig. METHODS Patch clamp technique with whole cell configuration. Holding potential was -40 mV, commanding potential was -100~+50 mV and duration was 600 ms. Pipette solution contained 0 3 mmol?L -1 ATP. RESULTS NMB inhibited I KATP in a concentration dependent manner. When holding potential was -40 mV and command potential was 0 mV, I KATP were reduced from (0 46?0 09) nA, (0 43?0 15) nA, and(0 47?0 10) nA to (0 37?0 07) nA( n=4,P

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Etude diagnostique langue: Chinois Texte intégral: Chinese Pharmacological Bulletin Année: 1986 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Etude diagnostique langue: Chinois Texte intégral: Chinese Pharmacological Bulletin Année: 1986 Type: Article