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Synthesis and antibacterial activity of 7-substituted-1-(2-fluoroethyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolone carboxylic acid compounds / 第二军医大学学报
Academic Journal of Second Military Medical University ; (12)2000.
Article Dans Chinois | WPRIM | ID: wpr-677196
ABSTRACT

Objective:

To study the synthesis and antibacterial activity of 7 substituted 1 (2 fluoroethyl) 6,8 difluoro 1, 4 dihydro 4 oxo 3 quinolone carboxylic acid compounds.

Methods:

The title compounds were synthesized by condensation,cyclization, nucleophilic substitution. Antibacterial activity in vitro was determined with 6 kinds of common pathogenic bacteria.

Results:

Eleven compounds of 7 substituted 1 (2 fluoroethyl) 6,8 difluoro 1,4 dihydro 4 oxo 3 quinolone carboxylic acid were designed and synthesized. These compounds were firstly reported. The chemical structures of all compounds were determined by IR, 1HNMR and elementary analysis. CompoundⅠ 1,Ⅰ 2,Ⅱ 4 showed better antibacterial activities than that of fleroxacin.

Conclusion:

Some of the title compounds show potent antibacterial activities and should be further studied. [

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Chinois Texte intégral: Academic Journal of Second Military Medical University Année: 2000 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Chinois Texte intégral: Academic Journal of Second Military Medical University Année: 2000 Type: Article