Effect of sodium ferulute on monophasic action potential of Ventricular muscle in rabbit / 中国药理学通报

ABSTRACT

AIM To study sodium ferulute on monophasic action potential of ventricular muscle. METHODS Well being rabbits( n =20) were divided into 2 groups randomly,benzyltetrahydroplmatine(BTHP)group is a control group,the other is a study group. Franz's Quadrupole contact electrod catheter is advanced into the rigter ventricular by vein.MAP is recorded by traditional methods. At the same time Ⅱ lead ECG was recorded. Control group and study group were administered BTHP(5 mg?kg -1 ) and sodium ferulute(0 6 g?kg -1 ) respectively,before and after administration the duration of MAP at 20%(MAPD20),50%(MAPD50) and 90% (MAPD90) repolarization,amplitude of MAP (MAPA) and effective refractory period(ERP)were measured. RESULT In control group MAPD50,MAPD90 and ERP were significantly prolonged (124 5?8 96) ms vs (97 5?6 77) ms,(153?7 53) ms vs (123 5?5 8) ms,(142?13 37) vs (111?13 50) ms,respectively, P 0 05). CONCLUSION Sodium ferulute may be potassium channel blocker.