EFFECTS OF PROCYANIDINS EXTRACT FROM THE LOTUS SEEDPOD ON REACTIVE OXYGEN SPECIES AND LIPID PEROXIDATION / 营养学报
Acta Nutrimenta Sinica
;
(6)1956.
Article
Dans Chinois
| WPRIM
| ID: wpr-677773
ABSTRACT
Objective:
To study the effects of procyanidins extract from the lotus seedpod (LSPC) on active oxygen radicals and lipid peroxidation.Methods:
(1) The scavenging effects of LSPC on O ?- 2 and ?OH was investigated by using chemiluminescence method; (2) The effects of different concentrations of LSPC on RBC auto oxidation and LPO formation of rat liver mitochondria in vitro were observed; (3) The LPO level of liver homogenates incubated with Fe 2+ and H 2O 2 in vitro were determined; (4) the mice were treated with a single intragastric feeding of 5% CCl 4 soya bean oil solution (10ml/kg bw) after seven days supplementation of LSPC 100, 200, 400 mg/(kg bw?d). The activities of SOD, GST and the level of LPO in liver and plasma of CCl 4 toxic mice were determined.Results:
In vitro, LSPC 169.0mg/L or 105.3mg/L was shown to markedly scavenge O ?- 2 produced in xanthine/xanthine oxidase and ?OH in Fenton systems respectively, and could significantly inhibit the formation of liver LPO. In vivo, LSPC (100,200mg/kg) evidently reduced the level of LPO and increase the activities of SOD and GST.Conclusion:
It suggests that LSPC may be used as an antioxidant and might effectively protect liver from the injury due to lipid peroxidation.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Acta Nutrimenta Sinica
Année:
1956
Type:
Article
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