Clinicopathological characteristics of extremely young Korean multiple myeloma patients: therapeutic implications
The Korean Journal of Internal Medicine
;
: 722-730, 2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-67784
ABSTRACT
BACKGROUND/AIMS:
Although multiple myeloma (MM) is typically a disease of the elderly, a certain subset of extremely young patients exists. It is necessary to establish clinicopathological characteristics for this population.METHODS:
We reviewed the medical records of MM patients whose age was 40 years or younger at diagnosis.RESULTS:
A total of 32 patients were analyzed (male to female ratio 1913, median age 37 years). According to International Staging System, 29%, 48%, and 16% were in stage I, II, and III, respectively. Light chain myeloma accounted for 30%. Clinically significant anemia, hypercalcemia, azotemia, and hypoalbuminemia were present in 29%, 28%, 13%, and 28%, respectively. Three or more lytic bone lesions were detected in 45% of the patients, whereas 13% had no lytic bone lesions. Regarding treatment, 79% of patients received autologous hematopoietic stem cell transplantation. After a median follow-up duration of 64 months, the 1-, 3-, and 5-year overall survival (OS) rates were 84%, 62%, and 54%, respectively. The median OS was 61 months for the entire cohort.CONCLUSIONS:
In our study, MM patients aged 40 years or younger at diagnosis showed no superior survival compared to those of the moderately elderly patients based on historical data.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Dossiers médicaux
/
Études de cohortes
/
Études de suivi
/
Résultat thérapeutique
/
Transplantation de cellules souches hématopoïétiques
/
Hypoalbuminémie
/
Diagnostic
/
Azotémie
/
Hypercalcémie
/
Anémie
Type d'étude:
Etude diagnostique
/
Etude d'étiologie
/
Etude d'incidence
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte très âgé
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
The Korean Journal of Internal Medicine
Année:
2017
Type:
Article
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