Effects of Saponin Extracted from Zea Mays L (ZMLS) on Pathogenic Diabetic Mouse Model Caused by Administration of Alloxan and Glucose / 中华中医药杂志

ABSTRACT

Objective: To observe the effects of Saponin Extracted from Zea Mays L(ZMLS) on reducing blood sugar in pathogenic diabetic mouse models.Methods: The pathogenic diabetic mouse models were established successfully by intravenous injection of small dose of alloxan and intragastric administration of glucose.Modeling state of pathogenic diabetic mice and the effects of Saponin Extracted from Zea Mays L(ZMLS) on pathogenic diabetic mouse models were observed through the levels of blood sugar and serum of insulin and the pathology changes of islet cells.Results: It was successful to establish pathogenic diabetic mouse models by intravenous injection of small dose of alloxan and intragastric administration of glucose.ZMLS had good action of lowering the level of blood glucose on this model and had good action of preventing the pancreatic island ?-cell from the injury induced by drugs.Conclusion: ZMLS has good therapy effects on pathogenic diabetic mouse models induced by intravenous injection of small dose of alloxan and intragastric administration of glucose.