Enrichment of T cells in the tumor and peripheral blood of prostate cancer patients and its significance / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
; (12)2006.
Article
Dans Zh
| WPRIM
| ID: wpr-680069
Responsable en Bibliothèque :
WPRO
ABSTRACT
Objective To investigate whether CD4~+CD25~(high)regulatory T cells(tregs)were increased in the tumor tissue and peripheral blood of prostate cancer patients.Methods The prevalence of CD4~+CD25~(high)regulatory T cells inside the prostate tumor was detected compared with benign tissue from the same prostate.Furthermore,the frequency of CD4~+CD25~(high)regulatory T cells in peripheral blood was detected in prostate cancer patients compared with normal donors.Results Moreover,CD4~+CD25~(high)regulatory T cells from blood and supernatants from cultured prostate tumor tissue samples exhibited immunosuppressive function in vitro.CD4~+CD25~(high)T normal peripheral blood cells were found for the ratio was(0.5?0.1)%.Lower than the proportion of T cells in peripheral blood of patients with CD4~+CD25~(high)was(2.3?0.7)%,P
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Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Journal of Primary Medicine and Pharmacy
Année:
2006
Type:
Article