PDTC reduces E-selectin expression on hypoxia/reoxygenation-stimulated endothelial cells / 中华胸心血管外科杂志
Article
de Zh
| WPRIM
| ID: wpr-682400
Bibliothèque responsable:
WPRO
ABSTRACT
Objective: To study the mechanisms and treatment of ischemia/reperfusion injury. Expression of E selectin was measured and the effect on suppression of E selectin by the Pyrrolidine Dithiocarbamate was investigated. Methods: Endothelial cells were exposed to hypoxia, then returned to reoxygenation condition. ELISA methods were used to detect expression of E selectin. Results: E selectin expression on hypoxia/reoxygenation stimulated endothelial cells increased, PDTC could suppress translation of E selectin effectively. Conclusion: It seems that E selectin may act as a critical factor. PDTC may prove beneficial in the treatment of ischemia/reperfusion injury.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Journal of Thoracic and Cardiovascular Surgery
Année:
2003
Type:
Article