High Selective Synthesis of 11?-hydroxycanrenone by Biotransformation / 微生物学通报
Microbiology
;
(12)1992.
Article
Dans Chinois
| WPRIM
| ID: wpr-685391
ABSTRACT
Canrenone is an important intermediate for the synthesis of eplerenone,a cardiovascular drug.C_ 11 ?-hydroxylation of canrenone is the key reaction,which can be done by microbial transformation.Rhizopus sp.SIPI-0602,kept in our lab,could high selectively transform canrenone to a compound named SIPI-11.By determining and analyzing the MS,UV,NMR etc.spectra of compound SIPI-11,its chemical structure was elucidated to be 11?-hydroxycanrenone.The study on flask transformation technology showed that the transformation ratio exceeded 90% when the substrate concentration was not more than 6g/L.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Microbiology
Année:
1992
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS