Expression of Inhibin in the Whole-body gamma-irradiated Mouse Ovary / 대한불임학회지
Korean Journal of Fertility and Sterility
;
: 35-44, 2006.
Article
Dans Coréen
| WPRIM
| ID: wpr-68615
ABSTRACT
OBJECTIVE:
The purposes of the present study were to investigate the effect of gamma-radiation on the expression of inhibin-alpha proteins and genes for inhibin alpha, betaA, and betain the ovary.METHODS:
Immature mice were whole-body gamma-irradiated with 25% of a lethal dose. At time 0, 3, 6, 12, and 24 hours after the irradiation,the ovaries were collected and used for immunohistochemistry for inhibin-alpha, and RT_PCR for inhibin-alpha, betaA, and betaB.RESULTS:
The expression of the immunoreactive inhibins-alpha was maintained at 12 hours post-irradiation and reduced thereafter. The expression of inhibin-alpha mRNA was significantly increased with the time after the irradiation. However there were no significant changes in the expression of betaA and betaB mRNAs.CONCLUSION:
It might be thought that inhibin acts as one of the regulatory factors in the gamma-radiation-induced follicular atresia in mice
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ovaire
/
ARN messager
/
Immunohistochimie
/
Atrésie folliculaire
/
Inhibines
Limites du sujet:
Animaux
langue:
Coréen
Texte intégral:
Korean Journal of Fertility and Sterility
Année:
2006
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS