Effects of Low-iodine Diet on the Expression of Homeobox Gene NKX-2.2 in Rat Cerebrum Tissue / 中国生物工程杂志
China Biotechnology
; (12)2006.
Article
de Zh
| WPRIM
| ID: wpr-686178
Bibliothèque responsable:
WPRO
ABSTRACT
Objective:To explore the influence of low-iodine diet on the expression of homeobox gene NKX-2.2 in rat cerebrum tissue,and to explain the possible molecular mechanism of cerebrum development retardation caused by low-iodine.Methods:Female Wistar rats were randomly divided into two groups:Low-iodine group and control group,both fed with low-iodine feed,given the deionized water and KIO3 solution respectively,they were drawn from the 16-day pregnancy,new-born and 20th days old low-iodine and normal age offspring after three months,and detect the content of NKX-2.2 mRNA in the cerebrum tissue by Real-time fluorescence quantitative PCR techniques.Results:The thyroid hormone levels of low-iodine group in serum were significantly lower than the control group(P
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WPRIM
langue:
Zh
Texte intégral:
China Biotechnology
Année:
2006
Type:
Article