Your browser doesn't support javascript.
loading
Relationships between Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: Clinical Assessments, Biomarkers, and Treatment / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 966-973, 2018.
Article Dans Anglais | WPRIM | ID: wpr-687001
ABSTRACT
<p><b>Objective</b>Rapid eye movement sleep behavior disorder (RBD) is characterized by dream enactment and loss of muscle atonia during rapid eye movement sleep. RBD is closely related to α-synucleinopathies including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Many studies have investigated the markers of imaging and neurophysiological, genetic, cognitive, autonomic function of RBD and their predictive value for neurodegenerative diseases. This report reviewed the progress of these studies and discussed their limitations and future research directions.</p><p><b>Data Sources</b>Using the combined keywords "RBD", "neurodegenerative disease", "Parkinson disease", and "magnetic resonance imaging", the PubMed/MEDLINE literature search was conducted up to January 1, 2018.</p><p><b>Study Selection</b>A total of 150 published articles were initially identified citations. Of the 150 articles, 92 articles were selected after further detailed review. This study referred to all the important English literature in full.</p><p><b>Results</b>Single-nucleotide polymorphisms in SCARB2 (rs6812193) and MAPT (rs12185268) were significantly associated with RBD. The olfactory loss, autonomic dysfunction, marked electroencephalogram slowing during both wakefulness and rapid eye movement sleep, and cognitive impairments were potential predictive markers for RBD conversion to neurodegenerative diseases. Traditional structural imaging studies reported relatively inconsistent results, whereas reduced functional connectivity between the left putamen and substantia nigra and dopamine transporter uptake demonstrated by functional imaging techniques were relatively consistent findings.</p><p><b>Conclusions</b>More longitudinal studies should be conducted to evaluate the predictive value of biomarkers of RBD. Moreover, because the glucose and dopamine metabolisms are not specific for assessing cognitive cognition, the molecular metabolism directly related to cognition should be investigated. There is a need for more treatment trials to determine the effectiveness of interventions of RBD on preventing the conversion to neurodegenerative diseases.</p>
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Maladie de Parkinson / Sang / Marqueurs biologiques / Protéines tau / Maladies neurodégénératives / Trouble du comportement en sommeil paradoxal / Polymorphisme de nucléotide simple / Protéines lysosomales membranaires / Récepteurs éboueurs / Génétique Type d'étude: Étude observationnelle / Étude pronostique Limites du sujet: Humains langue: Anglais Texte intégral: Chinese Medical Journal Année: 2018 Type: Article

Documents relatifs à ce sujet

MEDLINE

...
LILACS

LIS

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Maladie de Parkinson / Sang / Marqueurs biologiques / Protéines tau / Maladies neurodégénératives / Trouble du comportement en sommeil paradoxal / Polymorphisme de nucléotide simple / Protéines lysosomales membranaires / Récepteurs éboueurs / Génétique Type d'étude: Étude observationnelle / Étude pronostique Limites du sujet: Humains langue: Anglais Texte intégral: Chinese Medical Journal Année: 2018 Type: Article