Comparison of Clinical Characteristics, Curative Efficacy, Total Survival Rate and Progression -Free Survival Rate in Different Subtypes of Early Nasopharyngeal NK/T Cell Lymphoma / 中国实验血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To compare the clinical characteristics, clinical efficacy, overall survival rate and progression-free survival rate between different subtypes of early nasopharyngeal NK/T cell lymphoma.</p><p><b>METHODS</b>The clinical data of 83 patients with early nasopharyngeal NK/T cell lymphoma in our hospital were retrospectively analyzed, the 83 patients were divided into 2 group 59 cases of NK cell lymphoma as group A, 24 cases of cytotoxic T-cell phenotype as group B. The differences of clinical characteristics, clinical efficacy and survival prognosis were compared between the 2 groups.</p><p><b>RESULTS</b>The incidence rate of lesion and bone destruction in the group A was significantly lower than those in the group B (P<0.05). The total effective rate in the group A was (91.53%) significantly higher than that in group B (58.33%) (P<0.05), and overall survival rate (59.32%) and progression-free survival rate (45.76%) of 5 years in the group A were significantly higher than those in the group B (29.17%, 16.67%) (Log-rank=4.22, 4.41, P<0.05). Hemophagocytic syndrome was a risk factor for overall survival in patients with nasopharyngeal NK/T cell lymphoma (OR=3.03, 95%CI1.53-6.00, P<0.01), and sex, tumor subtype and involvement of lymph node were the related factors affecting progression-free survival (OR=2.01, 1.12, 3.68, 95% CI1.07∼3.77,1.05-1.19, 1.63-8.27, P<0.05).</p><p><b>CONCLUSION</b>In the patients with early nasopharyngeal NK/T cell lymphoma, T cell lymphoma as compared with NK cell lymphoma is more prone to local invasion with poor clinical efficacy, survival and prognosis, therefore, chemotherapy methods should be actively adopted to improve prognosis of patients in clinic.</p>