Clinical application of minimal residual disease detection in childhood acute leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 416-420, 2018.
Article
Dans Chinois
| WPRIM
| ID: wpr-689615
ABSTRACT
In recent years, great progress has been made in the treatment outcome of childhood acute leukemia with the improvement of chemotherapy regimens and the introduction of risk-stratified therapy; however, minimal residual disease (MRD) is still a difficult problem which affects the prognosis of acute leukemia. MRD influences the selection of chemotherapy regimens and recurrence risk stratification, and meanwhile, it can be used for prognostic prediction. At present, flow cytometry and polymerase chain reaction are mainly used for MRD detection. The next-generation sequencing also plays an important role in MRD detection, especially in MRD detection after stem cell transplantation. This article reviews the methodology and significance of MRD detection in childhood acute leukemia.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Thérapeutique
/
Leucémie aigüe myéloïde
/
Maladie résiduelle
/
Transplantation de cellules souches hématopoïétiques
/
Diagnostic
/
Leucémie-lymphome lymphoblastique à précurseurs B et T
/
Séquençage nucléotidique à haut débit
Type d'étude:
Etude diagnostique
/
Étude pronostique
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Contemporary Pediatrics
Année:
2018
Type:
Article
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