The diagnostic clinical value of sTFR and its compound parameters in the inflammatory bowel disease combined with iron deficiency anemia / 安徽医科大学学报

ABSTRACT

Objective To evaluate the value of serum soluble transferrin receptor ( sTFR) and sTFR-ferritin index (sTFR/LogSF) in diagnosing iron deficiency anemia ( IDA) with inflammatory bowel disease ( IBD) . Methods 161 patients with diagnosis of IBD was continuous collected, including 81 cases of Crohn's disease ( CD) and 80 cases of ulcerative colitis( UC) . Drawing venous blood to check complete blood count, iron metabolism, CRP, folic acid and vitamin B12 (VitB12) in the next morning with an empty stomach. According to the WHO anemia diag-nostic criterion, patients were divided into anemia group and non anemia group. The incidence and etiology of IBD were analysed. All patients with IBD were divided into iron deficiency anemia group and non iron deficiency group based on SF. Receiver-operating characteristic curve ( ROC curve) were applied to evaluate the value of sTFR and sTFR/LogSF in diagnosis of IDA with IBD. All the cases were followed till the endpoint of the study, lasted for 12 months at least. Results The incidence of IBD combined with anemia was 62. 1% (100/161), among which IDA and ACD hold up to 40. 0 % (40/100) and 14. 0% (14/100) respectively, while the mix of IDA and ACD ac-count for 26. 0% (26/100), and 10. 0% (10/100) was taken by lack of folic acid and VitB12. The level of sTFR and sTFR/LogSF in IDA group were obviously higher than those in non IDA group,and this difference was statisti-cally significant (U=655. 5,306. 0,P ＜0. 001). The AUC of sTFR/LogSF (0. 937) was higher than the AUC (0. 865) of sTFR. High sTfR levels ( ＞4. 7 mg/L) had a sensitivity of 77. 5% and a specificity of 86. 0%, whereas high sTfR/LogSF ( ＞2. 8) had a sensitivity of 87. 5% and a specificity of 90. 9% for the diagnosis of IDA. Both sTFR and sTFR/LogSF index were not correlated with CRP levels (r=0. 042,0. 958, P＞0. 05). Con-clusion The incidence of IBD combined anemia is high,among which IDA is common. By detecting serum sTFR/LogSF and sTfR,the diagnosis of IBD combined IDA may be more accurate.