Impact of hepatitis A vaccine intervention on treatment effect in children with asthma / 重庆医学

ABSTRACT

Objective To investigate the impact of hepatitis A vaccine (HAV) intervention on clinical manifestations and impulse oscillometry (IOS) pulmonary function in children with asthma.Methods Eighty asthma children in the pediatric department of the Southwest Hospital of Third Military Medical University were selected as the control group,78 children were in the intervention group.The attenuated live HAV was adopted to conduct the intervention.The clinical manifestations and IOS pulmonary function were observed in 6 months and 12 mohths after inoculation.The case control study and analysis were performed.Results The symptom control and partial control rate at 6 months after HAV vaccine intervention in the intervention group was 89.8 ％,which was higher than 86.3 ％ in the control group,but the difference was not statistically significant (P＞0.05).The symptom control and partial control rate at 12 months after intervention in the intervention group was 92.3％,which in the control group was 87.6％,the asthma symptoms control situation in the intervention group was improved markedly,the difference was statistically significant (P＜0.05).The peripheral airway viscosity resistance (R5-R20) at 6 months after HAV vaccine intervention in the intervention group was lower than that in the control group,but there was no statistically significant difference (P＞ 0.05);Zrs,Fres,R5 at 12 months after intervention in the intervention group were lower than those in the control group,the difference was statistically significant (P＜0.05).Conclusion HAV vaccine intervention could improve clinical symptoms control and IOS lung function in children with asthma after one year.HAV vaccination has a protective effect on asthma in children.