Progress on the construction of adenovirus vectors / 国际儿科学杂志

ABSTRACT

Adenovirus vectors are widely used in many fields such as in vitro and in vivo gene transduction,gene therapy,vaccination and oncolytic treatment.They have high titer,low pathogenicity,high transduction efficiency,wide infected tissue and no host cell genome integration and many other advantages,and are widely used in experimental and clinical research.In recent years,using different methods of experimental improvement of adenoviral vectors in the basic and clinical research has made great development,becoming the most promising aspect of the viral vectors.This article reviews the structure of adenovirus,the development characteristics of adenoviral vectors and the latest improvements,clinical applications and other aspects of research progress.