Updates on microRNA in intestinal epithelial barrier / 国际儿科学杂志

ABSTRACT

MicroRNAs are a group of large and highly conserved non-coding small stranded RNAs that regulate the gene expression by translational inhibition or mediated degradation of target proteins at post-transcriptional levels,which plays an important role in many biological processes,including cell apoptosis,immune response,tumorigenesis and nutritional metabolism.The intestinal epithelial barrier is the first defense to maintain the general physiological phenomenon,and its integrity is a critical factor of the maintenance of intestinal mucosal barrier function and intestinal homeostasis.This article reviews the biological function of miRNAsand their post-transcriptional regulation of the formation of intestinal epithelial barrier.