Research progress on the relationship between intestinal microbiota and bile acids / 国际儿科学杂志

ABSTRACT

Intestinal microbiome is a popular research field nowadays,which is involved in many kinds of metabolism and has significant relationship with many diseases in human.Gut microbiota is a part of microbiome and one of the guarantee of human health.Bile acid is an important digestive enzyme participating in the digestion and absorption of food.It is produced by the liver and enter the small intestine through the biliary systern.In recent years,many studies have shown that there are the closely related between the gut microbiota and bile acid.On the one hand,gut microbiota can encode a variety of enzymes,such as bile salt hydrolase and 7α-dehydroxylate,to effect the metabolism of bile acids and change the composition of bile acid pool.Bile acid pool,on the other hand,as a generic term of all kinds of bile acid,can directly inhibit the activity of bacteria or have indirect influence through regulating the intestinal barrier function on the distribution and growth of bacteria.Bile acids can also limit the overgrowth of pathogenic bacteria such as Clostridium difficile.This review,Summarizes the relationship between the gut microbiota and bile acid.