Research progress in epigenetics of the development of urinary system / 国际儿科学杂志

ABSTRACT

With the reciprocal inductive interactions between metanephric mesenchyme and ureteric bud,embryonic kidney cells gradually grow,proliferate,and differentiate,contribute to the formation of nephron and urinary collecting duct systems,and eventually develop into a mature urinary system. In this process,epigenetic modifier genes regulate the development of the urinary system;aberrant epigenetic modifications,however, will lead to congenital anomalies of kidney and urinary tract. Epigenetic factors,including histone modification, DNA methylation,and non-coding RNA,affect the development of the urinary system through the regulation of Wnt,GDNF / Ret,and p53 signaling pathways. This article combines with the latest research progress,reviews the role of epigenetic modifications in the development of the urinary system and during the formation of congenital anomalies of kidney and urinary tract;besides,the specific regulation mechanisms are explained.