Analysis of viral load and complications in children patients with severe hand-foot-mouth disease caused by enterovirus type 71 / 国际检验医学杂志

ABSTRACT

Objective To analyze the viral load and complications in children patients with severe hand-foot-mouth disease(HFMD) caused by enterovirus type 71(EV71) .Methods The clinical data in 320 children patients with severe HFMD caused by EV71 treated in this hospital from January 2013 to December 2016 were retrospectively analyzed .The viral load in children patients with severe EV 71 caused HFMD was detected by adopting the fluorescence quantitative polymerase chain reaction (Q-PCR) ,and its correlation with the compli-cations was analyzed .Results The viral load in the children patients with critical type HFMD was significant-ly higher than that in the children patient with severe type HFMD ,the difference was statistically significant (P<0 .05) .Compared with severe HFMD ,the incidence rate of nervous system damage ,respiratory failure , circulatory failure and myocardial damage in critical type HFMD were significantly increased ,the difference was statistically significant (P<0 .05) .Compared with the EV71 viral load in the children patients with asep-tic meningitis ,the EV71 viral load in the children patients with brainstem encephalitis and acute flaccid paraly-sis were increased significantly ,moreover the EV71 viral load in the children patients with acute flaccid paraly-sis was significantly higher than that in the children patients with brainstem encephalitis ,the difference was statistically significant (P<0 .05) .Conclusion The viral load in children patients with severe HFMD caused by EV71 is correlated with severity of disease condition and complications ,and the viral load detection is con-ducive to disease condition monitoring and guidance of clinical treatment .