The change and correlation of serum squamous cell carcinoma,interleukin-6 and transforming growth factor-β in cervical cancer / 国际检验医学杂志

ABSTRACT

Objective To investigate the change and correlation of serum squamous cell carcinoma,interleu-kin-6 and transforming grow th factor-β in cervical cancer.Methods A total of 58 patients with cervical cancer treated in our hospital from December 2015 to December 2016 were selected as the observation group,mean-while 41 healthy persons were recruited into the control group.The serum levels of SCC-Ag,IL-6 and TGF-β were compared between the two groups,different clinical stages and different degrees of differentiation of pa-tients in the observation group,the correlations between SCC-Ag and IL-6,TGF-β were analyzed.Results The serum levels of SCC-Ag,IL-6 and TGF-β in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The serum levels of SCC-Ag,IL-6 and TGF-β in the Ⅰ - Ⅱ phase were lower than those in the Ⅲ - Ⅳ phase,the differences were statistically significant(P<0.05).The serum levels of SCC-Ag,IL-6 and TGF-β in differentiated sera were lower than those in moderately differentiated and poorly differentiated ones,the contents of SCC-Ag,IL-6 and TGF-β in differentiated sera were lower than those in low differentiation,the differences were statistically significant(P<0.05).SCC-Ag was positively related to IL-6 and TGF-β(r=0.371,0.497,P<0.05).Conclusion The levels of SCC-Ag,IL-6 and TGF-β in patients with cervical cancer increased significantly with the severity of disease,and SCC-Ag was positively related to IL-6 and TGF-β.