Expression of chemokine receptor and vascular endothelial growth factor in ovarian cancer / 国际检验医学杂志

ABSTRACT

Objective To explore the correlation between chemokine receptor 4(CXCR4) and vascular en-dothelial growth factor (VEGF) and ovarian cancer.Methods 59 cases of oophorectomy were selected from February 2014 to April 2015.According to the pathological results,the patients were divided into ovarian canc-er group(group A) with 32 cases and benign tumor group (group B) with 27 cases.Another 35 patients un-dergoing non ovarian surgery were selected as control group (group C).The expressions of CXCR4 and VEGF in ovarian tissues of each group were detected,and the correlation with ovarian cancer was analyzed.Results The expression levels of CXCR4 and VEGF in the three groups were in the turn of A,B and C,and the differ-ence was statistically significant (P<0.05).The positive rate of VEGF was higher in low differentiation canc-er tissues,and the difference was statistically significant (P<0.05);the positive rate of VEGF was relatively high in the cancer tissues of clinical stage Ⅲ and IV,and the difference was statistically significant (P< 0. 05);the positive rates of CXCR4 and VEGF were higher in ovarian cancer with peritoneal metastasis or lymph node metastasis,and the difference was statistically significant (P<0.05).The expression of CXCR4 in ovarian canc-er tissues was positively correlated with the expression of VEGF (P<0.05).Conclusion CXCR4 and VEGF were highly expressed in ovarian cancer tissues,and the two involved in the development,invasion and metastasis of tumors.