Comparison of Icodextrin and 2.5% Glucose in Potassium Metabolism by Acute K+oad via Dialysate in Continuous Ambulatory Peritoneal Dialysis Patients
Electrolytes & Blood Pressure
;
: 25-30, 2009.
Article
Dans Anglais
| WPRIM
| ID: wpr-69285
ABSTRACT
This study aimed to compare the increment in plasma potassium concentration ([K+]) as well as the role of internal K+ balance for its changes following acute K+ supplementation between conventional 2.5% glucose (GD) and non-glucose containing dialysate (icodextrin, ID) in continuous ambulatory peritoneal dialysis (CAPD) patients. A total of 9 stable CAPD patients (5 men and 4 women; age, 56+/-13 years; 7 type-2 diabetics and 2 non-diabetics) on daily 4 exchanges of 2 L of glucose dialysate underwent the 6-hr dwell on fasting in the morning with 2 L of 2.5% glucose mixed with 20 mEq/L of KCl, and then the same regimen was repeated with icodextrin after 1-wk interval. The degree of intraperitoneal absorption was comparable, 65+/-2% in GD and 68+/-2% in ID, respectively (p=NS). However, despite the similar plasma K+ levels at the baseline of both regimens, its increment was significantly less in GD than ID, which was accompanied by more marked increase in the calculated intracellular K+ redistribution (68+/-3% vs. 52+/-3%, p<0.05). The basal levels of insulin were similar between the GD and ID groups. However, the change, checked up after 2 hours' dwell, from the basal insulin levels was much lower on ID. ID with a lesser degree of transcelluar K+ shift by the decreased secretion of insulin is more effective than the conventional glucose solution for acute K+ repletion via dialysate during CAPD. Furthermore, these results suggested that the role of insulin for the internal K+ balance was intact even in type-2 diabetic patients on CAPD
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Plasma sanguin
/
Potassium
/
Jeûne
/
Dialyse péritonéale continue ambulatoire
/
Absorption
/
Glucanes
/
Glucose
/
Hypokaliémie
/
Insuline
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Electrolytes & Blood Pressure
Année:
2009
Type:
Article
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