Research progress of microRNAs in precise radiotherapy for prostate cancer / 国际生物医学工程杂志

ABSTRACT

Radiotherapy is a very important treatment for early or advanced stage of prostate cancer (CaP).Radioresistance is the most important challenge for current radiotherapy.It is of great importance to study the mechanisms of radioresistance and to develop new treatment strategies that can overcome radioresistance.In CaP patients,microRNAs (miRNAs) are usually abnormally expressed,and radiotherapy can significantly alter the expression levels of miRNAs.There are increasing evidences that miRNAs are closely related to tumor radioresistance.The mechanism of action of miRNAs in regulating radioresistance is very complex.The possible mechanisms include DNA damage response,cell cycle checkpoint activation,apoptosis,autophagy,tumor stem cells,hypoxia,etc.The previous studies showed that miRNAs hold potential as prognostic biomarkers and therapeutic targets for CaP radiotherapy.New technologies targeting miRNAs combined with radiotherapy are expected to overcome CaP radioresistance,which will help to achieve precise radiotherapy,and bring hope to patients.